There are a few different ways to go about 3D printing organs.
Possibly one of the simplest ways to 3D print organs is to 3D print a scaffold using a biocompatible material and then grow the tissue cells on it.
This method works on monocellular tissues such as cartilage and, although making it actually function in the body is not as easy as it sounds, it was accomplished by Columbia University Medical Center (CUMC) researchers with meniscal tissues, responsible for the shock absorption in your knees.
“We envision that personalized meniscus scaffolds, from initial MRI to 3D printing, could be completed within days,” said Dr. Mao.
The personalized scaffolds would then be shipped to clinics and hospitals within a week, to be surgically implanted in the patient’s knee.
Mao explains further in the video below:
Columbia University Medical Center researchers have devised a way to replace the knee’s protective lining, called the meniscus, using a personalized 3D-printed implant, or scaffold, infused with human growth factors that prompt the body to regenerate the lining on its own. The therapy, successfully tested in sheep, could provide the first effective and long-lasting repair of damaged menisci, which occur in millions of Americans each year and can lead to debilitating arthritis.To put Mao’s explanation another way: an MRI scan of the intact meniscus in the undamaged knee would be converted into a 3D image.
The data from the 3D image is then used to 3D bio-print a scaffold in the exact shape of the meniscus using a polycaprolactone material, a biodegradable polymer. The machine used for the bioprinting process is EnvisionTEC’s bioplotter, which is capable of 3D printing with different materials at different temperatures.
The process implemented in this case is very similar to desktop FFF 3D printing, only at a microscopic level.Dr Mao’s work and theory on applying this process to humans is the result of a previous experiment successfully carried out in sheep and published under the title “Protein-Releasing Polymeric Scaffolds Induce Fibrochondrocytic Differentiation of Endogenous Cells for Knee Meniscus Regeneration in Sheep.”
He and his team, which also includes contributors Chang H. Lee, Chuanyong Lu, and Cevat Erisken (CUMC), Scott Rodeo of the Hospital for Special Surgery and Lisa Fortier (Cornell University), believe this approach also represents a departure from classic tissue engineering.
One where the stem cell regeneration process is “jumpstarted” inside the body, using factors that, by leveraging on the accurate deposition possible through the 3D printed scaffolding, promote tissue regeneration, thus helping the body to carry out the same additive process by which we all come to be and grow in the first place.
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